Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.31 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919238 | 0.95 | KCNN4 (0.42) | KCNN4KEAP1NFE2L2CHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL7930903 | 0.80 | KCNN4 (0.36) | KCNN4 | |
| Hydrochloric Acid SCHEMBL7930546 | 0.79 | KCNN4 (0.35) | KCNN4 | |
| Hydrochloric Acid SCHEMBL7919308 | 0.79 | KMT2A (0.38) | CHRM2CHRM4CHRM1CHRM3SLC6A2 | |
| SCHEMBL7927359 | 0.77 | KCNN4 (0.35) | KCNN4 | |
| SCHEMBL7925479 | 0.77 | KCNN4 (0.41) | KCNN4KEAP1NFE2L2CHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL7924762 | 0.76 | KCNN4 (0.41) | KCNN4KEAP1NFE2L2CHRM2CHRM4 | |
| SCHEMBL7919241 | 0.75 | KCNN4 (0.36) | KCNN4CHRM3 | |
| SCHEMBL7927204 | 0.75 | KCNN4 (0.43) | KCNN4KEAP1NFE2L2CHRM2CHRM3 | |
| SCHEMBL7924675 | 0.75 | KCNN4 (0.43) | KCNN4KEAP1NFE2L2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867454-B1 | POLYMERIZATION CATALYST AND PROCESS FOR PRODUCING POLYMERS | IDEMITSU KOSAN CO (JP) | 2001-03-21 | — | — | EP | disclosed |
| US-6075102-A | Polymerization catalyst and process for producing polymers | IDEMITSU KOSAN CO., LTD. (JP) | 2000-06-13 | — | — | US | disclosed |
| EP-0867454-A1 | POLYMERIZATION CATALYST AND PROCESS FOR PRODUCING POLYMERS | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1998-09-30 | — | — | EP | disclosed |