SCHEMBL7931087

SCHEMBL7931087

CCCOCc1cc2cc(Br)ccc2o1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.44
CYP2A6 P11509 1/20 0.41
IDO1 P14902 2/20 0.40
USP2 O75604 2/20 0.40
PIM1 P11309 1/20 0.40
MAOA P21397 1/20 0.39
ALDH1A1 P00352 4/20 0.38
HDAC3 O15379 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
HTT P42858 1/20 0.37
AGXT P21549 1/20 0.37
GRIN1 Q05586 1/20 0.37
GRIN2A Q12879 1/20 0.37
GRIN2B Q13224 1/20 0.37
GRIN2C Q14957 1/20 0.37
GPR35 Q9HC97 1/20 0.37
ALDH2 P05091 1/20 0.37
ALDH1A3 P47895 1/20 0.37
CA12 O43570 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31473816 0.81 IDO1 (0.55) CYP19A1CYP2A6IDO1USP2PIM1
SCHEMBL14265167 0.81 IDO1 (0.55) CYP19A1CYP2A6IDO1USP2PIM1
SCHEMBL18536343 0.80 AGXT (0.60) ALDH1A1AGXT
SCHEMBL7931595 0.79 HDAC6 (0.38) IDO1MAOAHDAC3HDAC1HDAC2
SCHEMBL6301307 0.79 CYP19A1 (0.49) CYP19A1CYP2A6USP2PIM1MAOA
SCHEMBL6300586 0.79 CYP19A1 (0.51) CYP19A1CYP2A6USP2PIM1MAOA
SCHEMBL30317998 0.79 CYP19A1 (0.51) CYP19A1CYP2A6USP2PIM1MAOA
SCHEMBL7931593 0.78 MAOB (0.36) MAOAAGXTCA12CA1CA2
SCHEMBL2333763 0.76 CYP19A1 (0.47) CYP19A1CYP2A6USP2PIM1MAOA
SCHEMBL7469284 0.75 ALOX15 (0.47) CYP19A1CYP2A6USP2PIM1MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140896-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 Takeda Chemical Industries, Ltd. (JP) 2001-10-10 EP disclosed
US-6235771-B1 AIDS THERPAY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
WO-2000037455-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-06-29 WO disclosed