Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Piconol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | PTPRA | P18433 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piconol SCHEMBL27593270 | 0.95 | HRH1 (0.54) | HRH3HRH1LMNASMN1; SMN2ALDH1A1 | |
| Piconol SCHEMBL29530498 | 0.93 | — | — | |
| Piconol SCHEMBL29266 | 0.93 | — | — | |
| Piconol SCHEMBL15050907 | 0.91 | — | — | |
| Piconol SCHEMBL28642302 | 0.91 | HRH1 (0.52) | HRH3HRH1LMNASMN1; SMN2ALDH1A1 | |
| Piconol SCHEMBL7153451 | 0.91 | — | — | |
| Piconol SCHEMBL2647157 | 0.91 | — | — | |
| Piconol SCHEMBL3074525 | 0.91 | — | — | |
| Piconol SCHEMBL7153449 | 0.91 | — | — | |
| Piconol SCHEMBL31122945 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873297-B1 | PROCESS FOR PREPARING HYDROXY-CONTAINING COMPOUNDS FROM FORMIC ACID ESTERS | BASF AG (DE) | 2001-07-04 | — | — | EP | disclosed |
| EP-0873297-A1 | PROCESS FOR PREPARING HYDROXY-CONTAINING COMPOUNDS FROM FORMIC ACID ESTERS | BASF AKTIENGESELLSCHAFT (DE) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997017319-A1 | PROCESS FOR PREPARING HYDROXY-CONTAINING COMPOUNDS FROM FORMIC ACID ESTERS | BASF AKTIENGESELLSCHAFT (DE) | 1997-05-15 | — | — | WO | disclosed |