Piconol

Piconol

SCHEMBL2647157

O.OCc1ccccn1

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Piconol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Piconol SCHEMBL31122945 1.00
Piconol SCHEMBL29266 0.97
Piconol SCHEMBL29530498 0.97
Piconol SCHEMBL2909774 0.95 HRH1 (0.48)
Piconol SCHEMBL3074525 0.95
Piconol SCHEMBL15050907 0.95
Piconol SCHEMBL7153449 0.95
Piconol SCHEMBL7153451 0.95
Piconol SCHEMBL28642302 0.95 HRH1 (0.52)
Piconol SCHEMBL19874569 0.95

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111910256-A Single crystal preparation method of caffeine impurity II 山东新华制药股份有限公司 2020-11-10 CN claimed
CN-111910256-A Single crystal preparation method of caffeine impurity II 山东新华制药股份有限公司 2020-11-10 CN disclosed
EP-2221311-B1 Novel nucleic acid base pair TAGCYX BIOTECHNOLOGIES (JP) 2013-08-21 EP disclosed
EP-1114827-B1 NOVEL NUCLEIC ACID BASE PAIR JAPAN SCIENCE & TECH AGENCY (JP) 2010-11-17 EP disclosed
EP-2223931-A1 Novel nucleic acid base pair Japan Science and Technology Agency (JP) 2010-09-01 EP disclosed
EP-2221311-A1 Novel nucleic acid base pair Japan Science and Technology Agency (JP) 2010-08-25 EP disclosed
US-7667031-B2 Nucleic acid base pair JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2010-02-23 US disclosed
US-20090286247-A1 Novel nucleic acid base pair JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2009-11-19 US disclosed
US-7101992-B1 Nucleic acid base pair JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2006-09-05 US disclosed
US-20050191689-A1 Novel nucleic acid base pair HIRAO, ICHIRO (JP) 2005-09-01 US disclosed
EP-1114827-A1 NOVEL NUCLEIC ACID BASE PAIR Japan Science and Technology Corporation (JP) 2001-07-11 EP disclosed
EP-0915875-A2 SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS MERCK SHARP &amp; DOHME LTD. (GB) 1999-05-19 EP disclosed
WO-1998004559-A2 SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS MERCK SHARP & DOHME LIMITED (GB) 1998-02-05 WO disclosed
US-5166078-A HAPTEN-MACROMOLECULE CONJUGATES USEFUL IN HAPTEN ASSAYS IDEXX LABORATORIES, INC. (US) 1992-11-24 US disclosed
EP-0256551-A2 Hapten-macromolecule conjugates useful in hapten assays AGRITECH SYSTEMS, Inc. (US) 1988-02-24 EP disclosed
US-4656036-A Antibiotics Tejeramycin and production thereof MERCK & CO., INC. (US) 1987-04-07 US disclosed
US-4482708-A VIRICIDES; POTENTIATION AND INDUCTION OF INTERFERON PRODUCTION NGUYEN NICOLAS C 1984-11-13 US disclosed