Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.62 |
| ▸ | BACE1 | P56817 | 9/20 | 0.62 |
| ▸ | BCHE | P06276 | 6/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20833260 | 0.82 | KDM4E (0.56) | DRD2DRD4DRD3LMNAMEN1 | |
| SCHEMBL22260238 | 0.82 | KDM4E (0.56) | DRD2DRD4DRD3LMNAMEN1 | |
| SCHEMBL11035988 | 0.81 | KDM4E (0.59) | DRD2DRD4DRD3LMNAMEN1 | |
| SCHEMBL7863136 | 0.78 | CCR3 (0.59) | ACHEALDH1A1 | |
| SCHEMBL1448700 | 0.78 | ACHE (0.62) | ACHEBACE1BCHELMNASIGMAR1 | |
| SCHEMBL14367985 | 0.77 | ACHE (1.00) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL22031918 | 0.77 | BACE1 (0.66) | ACHEBACE1BCHESIGMAR1 | |
| SCHEMBL21989908 | 0.77 | BACE1 (0.66) | ACHEBACE1BCHESIGMAR1 | |
| SCHEMBL4690024 | 0.77 | ACHE (0.69) | ACHEBACE1BCHESIGMAR1MEN1 | |
| SCHEMBL2498286 | 0.76 | ACHE (0.73) | ACHEBACE1BCHESIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |