Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8678524 | 1.00 | CYP1A2 (0.39) | CYP1A2TDP1HTTLMNAPAOX | |
| SCHEMBL12108450 | 0.75 | CYP1A2 (0.39) | CYP1A2TDP1PAOX | |
| SCHEMBL13197230 | 0.75 | CYP1A2 (0.39) | CYP1A2TDP1PAOX | |
| Hydrochloric Acid SCHEMBL7932347 | 0.75 | CYP1A2 (0.32) | CYP1A2TDP1 | |
| Hydrochloric Acid SCHEMBL7934507 | 0.74 | HTT (0.39) | CYP1A2TDP1HTTLMNA | |
| Hydrochloric Acid SCHEMBL8678620 | 0.74 | HTT (0.39) | CYP1A2TDP1HTTLMNA | |
| Hydrochloric Acid SCHEMBL7932369 | 0.72 | — | — | |
| SCHEMBL11402697 | 0.72 | CYP1A2 (0.37) | CYP1A2TDP1 | |
| Hydrochloric Acid SCHEMBL8678361 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL8679271 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169152-B1 | COPOLYMER OF ETHYLENE AND A POLAR GROUP-CONTAINING CYCLIC OLEFIN COMPRISING ESTER- OR ANHYDRIDE MODIFIED NORBORNENE OR PERHYDRO-2,3-DIDEHYDRO-1,4:5,8-DIMETHANONAPHTHALENE MADE WITH CATALYST SUCH AS 1,5,9-TRIAZACYCLODODECANYLTITANIUM CHLORIDE | JSR CORPORATION (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0816387-A1 | Olefin-polymerizing catalyst | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1998-01-07 | — | — | EP | disclosed |