Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 20/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 16/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 15/20 | 1.00 |
| ▸ | HRH1 | P35367 | 7/20 | 0.79 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.79 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.79 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7932392 | 1.00 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7930738 | 0.88 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7932393 | 0.86 | ADRA1A (0.76) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7924083 | 0.86 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7930753 | 0.85 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7932947 | 0.85 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7655720 | 0.84 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7930736 | 0.84 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7932938 | 0.84 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A | |
| SCHEMBL7934181 | 0.82 | ADRA1A (1.00) | ADRA1AADRA1BADRA1DHRH1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235759-B1 | BENIGN PROSTATIC HYPERPLASIA; HYPOTENSIVE AGENTS | MERCK & CO., INC. | 2001-05-22 | — | — | US | disclosed |
| WO-2000025782-A1 | DIHYDROPYRIDINONES AND PYRROLINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |