Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050699 | 0.91 | PTGS2 (0.60) | PTGS2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL6050619 | 0.91 | PTGS2 (0.60) | PTGS2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL7162856 | 0.84 | PTGS2 (0.51) | PTGS2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL6050727 | 0.82 | KDM4E (0.49) | PTGS2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL6050754 | 0.82 | KDM4E (0.49) | PTGS2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL6050705 | 0.77 | PTGS2 (0.52) | PTGS2KDM4EHPGD | |
| SCHEMBL6050740 | 0.77 | PTGS2 (0.61) | PTGS2KDM4EHPGD | |
| SCHEMBL20015818 | 0.77 | MAPT (0.59) | PTGS2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL12483144 | 0.75 | CHRNA7 (0.60) | PTGS2ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL20015932 | 0.75 | BCL2L1 (0.52) | PTGS2ALDH1A1MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3137648-B2 | — | — | 2001-02-26 | — | — | JP | claimed |
| EP-0679157-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1995-11-02 | — | — | EP | claimed |
| WO-1994015932-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1994-07-21 | — | — | WO | claimed |