Hydrochloric Acid

Hydrochloric Acid

SCHEMBL7933432

CC(C)P(c1ccccc1)c1ccccc1.[Cl-].[Cl-].[Ni+2]P(c1ccccc1)c1ccccc1

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
KDM4E B2RXH2 1/20 0.31
ESR1 P03372 1/20 0.30
ESR2 Q92731 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1582634 0.86 TDP1 (0.41) CYP3A4TDP1KDM4EESR1ESR2
SCHEMBL301134 0.86 TDP1 (0.45) CYP3A4TDP1KDM4EESR1ESR2
SCHEMBL4326950 0.84 TDP1 (0.43) CYP3A4TDP1ESR1ESR2
Bromide SCHEMBL28443974 0.84 TDP1 (0.43) CYP3A4TDP1KDM4EESR1ESR2
Bromide SCHEMBL29193727 0.84 TDP1 (0.43) CYP3A4TDP1KDM4EESR1ESR2
Iodide SCHEMBL1478204 0.84 TDP1 (0.43) CYP3A4TDP1KDM4EESR1ESR2
Bromide SCHEMBL1582391 0.81 TDP1 (0.41) CYP3A4TDP1KDM4EESR1ESR2
Ethane SCHEMBL3943018 0.81 CYP3A4 (0.45) CYP3A4TDP1KDM4EESR1ESR2
Hydrochloric Acid SCHEMBL5760985 0.78 CYP3A4 (0.35) CYP3A4TDP1ESR1ESR2
Hydrochloric Acid SCHEMBL5659847 0.78 CYP3A4 (0.40) CYP3A4TDP1ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828768-B1 HOMOPOLYMERS AND COPOLYMERS OF CATIONICALLY POLYMERIZABLE MONOMERS AND METHOD OF THEIR PREPARATION GOODRICH CO B F (US) 2001-04-18 EP disclosed
EP-0828768-A1 HOMOPOLYMERS AND COPOLYMERS OF CATIONICALLY POLYMERIZABLE MONOMERS AND METHOD OF THEIR PREPARATION The B.F. Goodrich Company (US) 1998-03-18 EP disclosed
US-5677405-A COPOLYMER OF NORBORNENE-TYPE MONOMER WHICH UNDERGOES ADDITION POLYMERIZATION AND CATIONICALLY POLYMERIZABLE MONOMER THE B.F. GOODRICH COMPANY (US) 1997-10-14 US disclosed
WO-1996037529-A1 HOMOPOLYMERS AND COPOLYMERS OF CATIONICALLY POLYMERIZABLE MONOMERS AND METHOD OF THEIR PREPARATION THE B.F. GOODRICH COMPANY (US) 1996-11-28 WO disclosed
EP-0353667-A1 Bithienyl derivatives, process for their preparation, and compositions containing them BASF Aktiengesellschaft (DE) 1990-02-07 EP disclosed