Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.43 |
| ▸ | DRD1 | P21728 | 5/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 8/20 | 0.42 |
| ▸ | DRD4 | P21917 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533054 | 0.91 | DRD2 (0.44) | DRD2DRD1TRPM8DRD3DRD4 | |
| SCHEMBL7533056 | 0.91 | DRD2 (0.44) | DRD2DRD1TRPM8DRD3DRD4 | |
| SCHEMBL7513671 | 0.88 | DRD2 (0.43) | DRD2DRD1TRPM8DRD3DRD4 | |
| SCHEMBL7513668 | 0.88 | DRD2 (0.43) | DRD2DRD1TRPM8DRD3DRD4 | |
| SCHEMBL7930304 | 0.86 | DRD2 (0.48) | DRD2DRD1DRD3DRD4ADRA1D | |
| SCHEMBL7923925 | 0.85 | DRD2 (0.43) | DRD2DRD1TRPM8DRD3DRD4 | |
| SCHEMBL7521684 | 0.83 | DRD2 (0.62) | DRD2DRD1DRD3DRD4CYP1A2 | |
| SCHEMBL7521679 | 0.83 | DRD2 (0.62) | DRD2DRD1DRD3DRD4CYP1A2 | |
| Hydrochloric Acid SCHEMBL7516152 | 0.83 | DRD2 (0.61) | DRD2DRD1DRD3DRD4CYP1A2 | |
| Hydrochloric Acid SCHEMBL7516146 | 0.83 | DRD2 (0.61) | DRD2DRD1DRD3DRD4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232348-B1 | AGONISTS OF THE DOPAMINERGIC RECEPTORS MORE POTENT THAN DOPAMINE AND OTHER KNOWN COMPOUNDS, DEPRIVED OF INTERACTION WITH OTHER RECEPTORS AND ORALLY BIOAVAILABLE WITH A LONG TERM OF ACTION | ZAMBON GROUP S.P.A. (IT) | 2001-05-15 | — | — | US | disclosed |