Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | F9 | P00740 | 3/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365024 | 0.86 | MAPT (0.51) | MAPTTP53SMN1; SMN2POLBNOTUM | |
| SCHEMBL2396935 | 0.82 | MAPT (0.47) | MAPTTP53SMN1; SMN2POLBNOTUM | |
| SCHEMBL2400241 | 0.75 | MAPT (0.52) | MAPTTP53SMN1; SMN2POLBCYP2D6 | |
| SCHEMBL2396967 | 0.73 | EPHX2 (0.48) | MAPTTP53SMN1; SMN2POLBCYP2C9 | |
| SCHEMBL2215697 | 0.71 | NOTUM (0.49) | MAPTTP53SMN1; SMN2POLBNOTUM | |
| SCHEMBL2396932 | 0.70 | MAPT (0.42) | MAPTTP53SMN1; SMN2POLBACLY | |
| SCHEMBL12263160 | 0.67 | NOTUM (0.55) | MAPTTP53SMN1; SMN2POLBNOTUM | |
| SCHEMBL2214728 | 0.67 | CNR1 (0.45) | MAPTTP53SMN1; SMN2POLBNOTUM | |
| SCHEMBL2399017 | 0.67 | MAPT (0.46) | MAPTTP53SMN1; SMN2POLBNOTUM | |
| SCHEMBL2218692 | 0.66 | HDAC1 (0.42) | MAPTTP53SMN1; SMN2POLBNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033626-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOLE AND TRIAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2010-03-25 | — | — | WO | disclosed |