Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2752527 | 0.80 | HTR6 (0.41) | HTR6AKT1AKT2CA12CA9 | |
| SCHEMBL8443781 | 0.80 | BRD4 (0.44) | HTR6CA12CA9L3MBTL1CA1 | |
| SCHEMBL2280274 | 0.80 | BRD4 (0.45) | HTR6CA12CA9L3MBTL1PIM1 | |
| SCHEMBL3348977 | 0.79 | HTR6 (0.48) | HTR6DRD2HTR2AHTR7ELAVL1 | |
| SCHEMBL3348822 | 0.78 | HTR6 (0.40) | HTR6CA12CA9L3MBTL1CA1 | |
| SCHEMBL8443783 | 0.78 | BCL2L1 (0.41) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL13745605 | 0.77 | PTPN11 (0.45) | HTR6CA12CA9CA1CA2 | |
| SCHEMBL2274807 | 0.77 | BRD4 (0.50) | HTR6CA12CA9L3MBTL1CA1 | |
| SCHEMBL8480893 | 0.76 | BRD4 (0.38) | HTR6CA12CA9CHUKDRD2 | |
| SCHEMBL8469870 | 0.76 | BRD4 (0.38) | HTR6CA12CA9L3MBTL1CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015803-A1 | DIAZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R & D MANAGEMENT CO. LTD (JP) | 2010-02-11 | — | — | WO | disclosed |