Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7936744 | 0.84 | ALDH1A1 (0.58) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL12225979 | 0.80 | NPC1 (0.42) | ALDH1A1MAPTMEN1KMT2ATSHR | |
| SCHEMBL10333387 | 0.80 | ALDH1A1 (0.63) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL12225963 | 0.74 | KMT2A (0.65) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL28426494 | 0.71 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAPOLBTSHR | |
| SCHEMBL8186954 | 0.71 | ALDH1A1 (1.00) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL14133293 | 0.70 | MEN1 (0.77) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL28463423 | 0.69 | ALDH1A1 (0.59) | ALDH1A1MAPTMEN1KMT2ATSHR | |
| SCHEMBL7932484 | 0.68 | ALDH1A1 (0.71) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL7934631 | 0.67 | ALDH1A1 (0.60) | ALDH1A1TDP1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010034003-A2 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2010-03-25 | — | — | WO | disclosed |