Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Homidium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.97 |
| ▸ | MAPT | P10636 | 5/20 | 0.97 |
| ▸ | BLM | P54132 | 4/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.97 |
| ▸ | HPGD | P15428 | 4/20 | 0.97 |
| ▸ | HTT | P42858 | 4/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.97 |
| ▸ | THRB | P10828 | 3/20 | 0.97 |
| ▸ | CASP1 | P29466 | 3/20 | 0.97 |
| ▸ | RECQL | P46063 | 3/20 | 0.97 |
| ▸ | CASP7 | P55210 | 3/20 | 0.97 |
| ▸ | TERT | O14746 | 3/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.97 |
| ▸ | MITF | O75030 | 2/20 | 0.97 |
| ▸ | NSD2 | O96028 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homidium SCHEMBL3025214 | 0.99 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL7751164 | 0.99 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL29376492 | 0.99 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL29498260 | 0.99 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL20520 | 0.99 | MEN1 (1.00) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL8777149 | 0.97 | MEN1 (0.97) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL8173023 | 0.97 | MEN1 (0.97) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL7865388 | 0.97 | MEN1 (0.97) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL3887854 | 0.97 | MEN1 (0.94) | MEN1KMT2AMAPTBLMKDM4E | |
| Homidium SCHEMBL2715995 | 0.97 | MEN1 (0.97) | MEN1KMT2AMAPTBLMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37206-E1 | FOR GLYCOSYLATING INDOLOPYRROLOCARBAZOLE DERIVATIVES CONVENIENTLY AND ECONOMICALLY | BANYU PHARMACEUTICAL CO, LTD (JP) | 2001-06-05 | — | — | US | disclosed |