Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7934755 | 0.86 | KDM4E (0.34) | SMN1; SMN2KDM4ELMNACYP2D6MEN1 | |
| SCHEMBL7155572 | 0.83 | MYC (0.33) | ALDH1A1 | |
| Trifluoromethanesulfonic Acid SCHEMBL7937107 | 0.79 | CYP2D6 (0.31) | CYP2D6 | |
| SCHEMBL3798506 | 0.79 | HTR2A (0.38) | SMN1; SMN2KDM4ELMNACYP2D6MEN1 | |
| Hydrochloric Acid SCHEMBL7644899 | 0.77 | HTR2A (0.36) | SMN1; SMN2KDM4ELMNACYP2D6MEN1 | |
| Hydrochloric Acid SCHEMBL4475457 | 0.77 | HTR2A (0.36) | SMN1; SMN2KDM4ELMNACYP2D6MEN1 | |
| Biphenyl SCHEMBL9342597 | 0.73 | HTR2A (0.33) | ALDH1A1SMN1; SMN2KDM4ELMNACYP2D6 | |
| Toluene SCHEMBL180606 | 0.70 | SMN1; SMN2 (0.65) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| SCHEMBL932442 | 0.70 | SMN1; SMN2 (0.73) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| SCHEMBL13836876 | 0.70 | SMN1; SMN2 (0.73) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329465-B1 | TRANSPARENCY, MECHANICAL STRENGTH AND MOLDABILITY | MITSUI CHEMICAL INC (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1086963-A1 | USE OF ETHYLENE/$g(a)-OLEFIN COPOLYMER AND USE OF ETHYLENE COPOLYMER COMPOSITION | Mitsui Chemicals, Inc. (JP) | 2001-03-28 | — | — | EP | disclosed |
| EP-0982362-A1 | ETHYLENE COPOLYMER COMPOSITION AND USE THEREOF | Mitsui Chemicals, Inc. (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5840808-A | Process for preparing olefin polymer | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| EP-0763553-A1 | PROCESS FOR PREPARING OLEFIN POLYMER | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-19 | — | — | EP | disclosed |