Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Tetraphenylphosphonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 6/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraphenylphosphonium SCHEMBL158514 | 0.96 | HIF1A (0.47) | HIF1AMAPTHPGDSMN1; SMN2MGLL | |
| Tetraphenylphosphonium SCHEMBL18936425 | 0.93 | HIF1A (0.45) | HIF1AMAPTHPGDSMN1; SMN2MGLL | |
| Tetraphenylphosphonium SCHEMBL7906432 | 0.93 | HIF1A (0.45) | HIF1AMAPTHPGDSMN1; SMN2MGLL | |
| Tetraphenylphosphonium SCHEMBL7931760 | 0.93 | HIF1A (0.45) | HIF1AMAPTHPGDSMN1; SMN2MGLL | |
| Tetraphenylphosphonium SCHEMBL3300848 | 0.93 | HIF1A (0.45) | HIF1AMAPTHPGDSMN1; SMN2MGLL | |
| Tetraphenylphosphonium SCHEMBL7934968 | 0.93 | HIF1A (0.45) | HIF1AMAPTHPGDSMN1; SMN2MGLL | |
| Tetraphenylphosphonium SCHEMBL29362652 | 0.93 | HIF1A (0.50) | HIF1AMAPTHPGDSMN1; SMN2MGLL | |
| Tetraphenylphosphonium SCHEMBL7931797 | 0.90 | HIF1A (0.43) | HIF1AMAPTHPGDSMN1; SMN2MGLL | |
| Tetraphenylphosphonium SCHEMBL108817 | 0.89 | HIF1A (0.47) | HIF1AMAPTHPGDSMN1; SMN2MGLL | |
| Tetraphenylphosphonium SCHEMBL19921940 | 0.89 | HIF1A (0.47) | HIF1AMAPTHPGDSMN1; SMN2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0834496-B1 | Preparation of diaryl carbonate | UBE INDUSTRIES (JP) | 2001-08-16 | — | — | EP | disclosed |
| EP-0834495-B1 | Process for preparing diaryl carbonate | UBE INDUSTRIES (JP) | 2000-12-27 | — | — | EP | disclosed |
| US-5892089-A | FROM DIARYL OXALATE IN LIQUID PHASE BY DECARBONYLATION USING ORGANIC PHOSHORUS COMPOUND CATALYST | UBE INDUSTRIES, LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| US-5892091-A | PHOSPHOROUS CATALYSTS AND HALOGEN ATOMS | UBE INDUSTRIES, LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0737665-B1 | Process for preparation of diaryl carbonate | UBE INDUSTRIES (JP) | 1998-10-21 | — | — | EP | disclosed |
| US-5792883-A | Preparation of diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1998-08-11 | — | — | US | disclosed |
| EP-0834496-A1 | Preparation of diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1998-04-08 | — | — | EP | disclosed |
| EP-0834495-A1 | Process for preparing diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1998-04-08 | — | — | EP | disclosed |
| EP-0826658-A1 | Catalyst for decarbonylation reaction | UBE INDUSTRIES, LTD. (JP) | 1998-03-04 | — | — | EP | disclosed |
| US-5648510-A | DECARBONYLATION OF OXALATE | UBE INDUSTRIES, LTD. (JP) | 1997-07-15 | — | — | US | disclosed |
| EP-0737665-A1 | Process for preparation of diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1996-10-16 | — | — | EP | disclosed |