Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | GALR1 | P47211 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7938682 | 0.94 | CHRNB4 (0.33) | CHRNB4CHRNA3NISCHPARP10PARP11 | |
| Hydrochloric Acid SCHEMBL27545985 | 0.93 | NISCH (0.38) | CHRNB4CHRNA3NISCHPARP10PARP11 | |
| Hydrochloric Acid SCHEMBL7932885 | 0.80 | CHRNB4 (0.34) | CHRNB4CHRNA3NISCHPARP10PARP11 | |
| Hydrochloric Acid SCHEMBL7936946 | 0.75 | CHRNB4 (0.33) | CHRNB4CHRNA3NISCHTAAR1ESR2 | |
| Hydrochloric Acid SCHEMBL27519803 | 0.74 | NISCH (0.38) | CHRNB4CHRNA3NISCHPARP10PARP11 | |
| Hydrochloric Acid SCHEMBL9348078 | 0.72 | DYRK1A (0.46) | NISCHGSK3BCLK4CYP3A4 | |
| Hydrochloric Acid SCHEMBL27519512 | 0.71 | NISCH (0.38) | CHRNB4CHRNA3NISCHPARP10PARP11 | |
| Hydrochloric Acid SCHEMBL27520974 | 0.71 | NISCH (0.42) | NISCH | |
| Hydrochloric Acid SCHEMBL7937003 | 0.66 | TAAR1 (0.34) | CHRNB4CHRNA3NISCHPARP10PARP11 | |
| Hydrochloric Acid SCHEMBL7935706 | 0.66 | NISCH (0.34) | CHRNB4CHRNA3NISCHPARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |