Hydrochloric Acid

Hydrochloric Acid

SCHEMBL7935978

C1=CC(c2ccc3ccccc3c2)=C([Hf+2](C2=C(c3ccc4ccccc4c3)C=CC2)=[Si](c2ccccc2)c2ccccc2)C1.[Cl-].[Cl-]

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 1/20 0.33
CYP1B1 Q16678 1/20 0.33
NISCH Q9Y2I1 1/20 0.33
CYP17A1 P05093 1/20 0.32
CYP19A1 P11511 1/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
GSTP1 P09211 1/20 0.32
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
ALOX5 P09917 1/20 0.31
HSD17B1 P14061 1/20 0.30
HSD17B2 P37059 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
TP53 P04637 1/20 0.30
CYP1A2 P05177 1/20 0.30
KMT2A Q03164 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7938958 0.83 NISCH (0.34) NISCHCYP17A1CYP19A1CYP11B1CYP11B2
Hydrochloric Acid SCHEMBL7935926 0.77 NISCH (0.36) NISCHTP53
Hydrochloric Acid SCHEMBL7938822 0.75 NISCH (0.34) NISCHCYP17A1CYP19A1CYP11B1CYP11B2
Hydrochloric Acid SCHEMBL7935817 0.74 NISCH (0.31) NISCHCYP17A1CYP19A1CYP11B1CYP11B2
Hydrochloric Acid SCHEMBL7926566 0.73 CYP1A1 (0.33) CYP1A1CYP1B1NISCHCYP17A1CYP19A1
Hydrochloric Acid SCHEMBL7936857 0.71 CYP1A1 (0.32) CYP1A1CYP1B1NISCHCYP17A1CYP19A1
Hydrochloric Acid SCHEMBL10320026 0.67
SCHEMBL6662036 0.65 GSTP1 (0.37) NISCHCYP17A1CYP19A1CYP11B1CYP11B2
Hydrochloric Acid SCHEMBL7926441 0.64 NISCH (0.34) NISCHCYP17A1CYP19A1CYP11B1CYP11B2
Hydrochloric Acid SCHEMBL7744045 0.62 CYP1A1 (0.33) CYP1A1CYP1B1NISCHGSTP1ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6184402-B1 RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES CHISSO CORPORATION (JP) 2001-02-06 US disclosed