SCHEMBL7936407

SCHEMBL7936407

COc1cccc(C(=O)C=O)c1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR2 O60603 2/20 0.56
TLR1 Q15399 2/20 0.56
TLR6 Q9Y2C9 2/20 0.56
ERN1 O75460 1/20 0.56
NR1H4 Q96RI1 1/20 0.52
KDM4E B2RXH2 3/20 0.52
MAPT P10636 3/20 0.52
ALOX15 P16050 2/20 0.52
MAPK1 P28482 2/20 0.52
HSD17B10 Q99714 2/20 0.52
LMNA P02545 2/20 0.52
ALDH1A1 P00352 2/20 0.52
TP53 P04637 1/20 0.52
CYP3A4 P08684 1/20 0.52
HPGD P15428 1/20 0.52
ALOX12 P18054 1/20 0.52
TAS1R3 Q7RTX0 2/20 0.50
TAS1R1 Q7RTX1 2/20 0.50
KLKB1 P03952 1/20 0.49
TAS1R2 Q8TE23 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29954715 0.83 ABCG2 (0.64) ABCG2NPC1HTTSMN1; SMN2AR
SCHEMBL1697561 0.83 ABCG2 (0.64) ABCG2NPC1HTTSMN1; SMN2AR
SCHEMBL6635025 0.82 NPC1 (0.50) KDM4EMAPTMAPK1HSD17B10ALDH1A1
Water SCHEMBL3048073 0.81 ABCG2 (0.62) ABCG2NPC1HTTSMN1; SMN2AR
SCHEMBL480276 0.81 KDM4E (0.59) TLR2TLR1TLR6ERN1NR1H4
SCHEMBL30463054 0.81 KDM4E (0.59) TLR2TLR1TLR6ERN1NR1H4
SCHEMBL29360359 0.79 MAPT (0.59) TLR2TLR1TLR6ERN1KDM4E
SCHEMBL2066210 0.79 KDM4E (0.57) TLR2TLR1TLR6ERN1NR1H4
SCHEMBL22588880 0.79 KDM4E (0.57) TLR2TLR1TLR6ERN1NR1H4
SCHEMBL29502905 0.79 LMNA (0.57) TLR2TLR1TLR6ERN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6184421-B1 SELECTIVE OXIDATION, TO A CARBOXY GROUP, OF THE GROUP IN THE 2 POSITION WITH RESPECT TO THE HYDROXYL GROUPS OF A MIXTURE OF PHENOLS HAVING FORMYL AND/OR HYDROXYMETHYL GROUPS IN POSITIONS 2 OR 4; PREPARING VANILLIN AND ETHYL VANILLIN RHODIA CHIMIE (FR) 2001-02-06 US disclosed