Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.82 |
| ▸ | ITGAV | P06756 | 20/20 | 0.82 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.57 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.46 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.46 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942792 | 1.00 | ITGB3 (0.82) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL7936622 | 1.00 | ITGB3 (0.82) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL7945639 | 1.00 | ITGB3 (0.82) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL7945568 | 0.91 | ITGAV (1.00) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL3888804 | 0.91 | ITGAV (1.00) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL3888492 | 0.91 | ITGAV (1.00) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL3888493 | 0.91 | ITGAV (1.00) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL4381844 | 0.86 | ITGAV (0.61) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7947765 | 0.86 | ITGAV (0.61) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7936743 | 0.86 | ITGAV (0.61) | ITGB3ITGAVITGA2BITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066648-A | USEFUL IN INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH | MERCK & CO., INC. (US) | 2000-05-23 | — | — | US | claimed |
| US-6268378-B1 | TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH. | MERCK & CO., INC. | 2001-07-31 | — | — | US | disclosed |
| US-6066648-A | USEFUL IN INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH | MERCK & CO., INC. (US) | 2000-05-23 | — | — | US | disclosed |