Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.57 |
| ▸ | TUBB | P07437 | 2/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7936791 | 0.91 | PRNP (0.55) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL7945788 | 0.88 | ESR1 (0.53) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL7106224 | 0.86 | MAPT (0.55) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL7103621 | 0.84 | MAPT (0.51) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL8643567 | 0.82 | TUBB4A (0.58) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL7936838 | 0.81 | TUBB4A (0.57) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL7944406 | 0.81 | TUBB4A (0.57) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6832588 | 0.81 | TUBB4A (0.57) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6812421 | 0.81 | TUBB4A (0.57) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL26625250 | 0.79 | TUBB4A (0.49) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258826-B1 | HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS | ELI LILLY AND COMPANY | 2001-07-10 | — | — | US | claimed |
| US-6087378-A | THE ACTIVE BENZO(B)THIOPHENE COMPOUNDS FOR TREATING OSTEOPOROSIS AND CARDIOVASCULAR DISORDERS, ESPECIALLY HYPERLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2000-07-11 | — | — | US | claimed |
| US-6258826-B1 | HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS | ELI LILLY AND COMPANY | 2001-07-10 | — | — | US | disclosed |
| US-6087378-A | THE ACTIVE BENZO(B)THIOPHENE COMPOUNDS FOR TREATING OSTEOPOROSIS AND CARDIOVASCULAR DISORDERS, ESPECIALLY HYPERLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| US-4588484-A | Electrochemical reduction of 3-chlorobenzo[b]thiophenes | ELI LILLY AND COMPANY (US) | 1986-05-13 | — | — | US | disclosed |