SCHEMBL7936856

SCHEMBL7936856

CC1C([Si](C)(C)Cl)=Cc2c1ccc1c2ccc2ccccc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 3/20 0.40
MAPT P10636 2/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.36
APEX1 P27695 1/20 0.36
MAPK1 P28482 1/20 0.36
PMP22 Q01453 1/20 0.36
PAX8 Q06710 1/20 0.35
ALDH1A1 P00352 4/20 0.34
HSD17B10 Q99714 4/20 0.34
TDP1 Q9NUW8 2/20 0.34
CYP2A6 P11509 1/20 0.34
TSHR P16473 1/20 0.34
KDM4E B2RXH2 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.31
CYP1A2 P05177 2/20 0.31
HPGD P15428 2/20 0.31
HIF1A Q16665 1/20 0.31
CYP1B1 Q16678 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7935709 0.80 HPRT1 (0.35) HPRT1MAPTLMNACYP3A4APEX1
SCHEMBL7630738 0.71 HPRT1 (0.42) HPRT1MAPTLMNACYP3A4APEX1
SCHEMBL7935685 0.70 HPRT1 (0.39) HPRT1MAPTLMNACYP3A4APEX1
SCHEMBL7637891 0.68 HPRT1 (0.39) HPRT1MAPTLMNACYP3A4APEX1
SCHEMBL7629651 0.67 HPRT1 (0.45) HPRT1MAPTLMNACYP3A4APEX1
SCHEMBL15848330 0.66 HPRT1 (0.54) HPRT1MAPTLMNACYP3A4APEX1
SCHEMBL1825938 0.66 CYP2A6 (0.36) HPRT1MAPTLMNACYP3A4MAPK1
SCHEMBL10877850 0.64 HPRT1 (0.45) HPRT1MAPTLMNACYP3A4APEX1
Chrysene SCHEMBL384031 0.63 HPRT1 (1.00) HPRT1MAPTLMNACYP3A4APEX1
SCHEMBL25510 0.63 HPRT1 (1.00) HPRT1MAPTLMNACYP3A4APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6329486-B1 PHYSICAL PROPERTIES THE DOW CHEMICAL COMPANY 2001-12-11 US disclosed
US-6323294-B1 CONTACTING C.SUB.2-100,000 OLEFIN/S UNDER POLYMERIZATION CONDITIONS WITH CATALYST SYSTEM COMPRISING METAL COMPLEX AND ACTIVATING COCATALYST OR REACTION PRODUCT OF METAL COMPLEX AND COCATALYST TO FORM ADDITION POLYMER THE DOW CHEMICAL COMPANY 2001-11-27 US disclosed
EP-1017701-A1 CYCLOPENTAPHENANTHRENEYL METAL COMPLEXES AND POLYMERIZATION PROCESS THE DOW CHEMICAL COMPANY (US) 2000-07-12 EP disclosed
WO-1999014221-A1 CYCLOPENTAPHENANTHRENEYL METAL COMPLEXES AND POLYMERIZATION PROCESS THE DOW CHEMICAL COMPANY (US) 1999-03-25 WO disclosed