Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 18/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216980 | 0.81 | ATM (0.49) | ATM | |
| SCHEMBL7926997 | 0.80 | PTPN1 (0.48) | PDGFRBKDR | |
| SCHEMBL3227602 | 0.70 | KMT2A (0.43) | ATM | |
| SCHEMBL13429218 | 0.70 | KDM4E (0.44) | ATM | |
| SCHEMBL13429221 | 0.69 | JAK2 (0.48) | — | |
| SCHEMBL13429299 | 0.67 | MEN1 (0.43) | — | |
| SCHEMBL2597849 | 0.67 | HTT (0.64) | ATM | |
| SCHEMBL13429223 | 0.66 | FYN (0.49) | — | |
| SCHEMBL15601909 | 0.65 | MAPT (0.53) | KDR | |
| SCHEMBL5406340 | 0.65 | F7 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030967-A1 | 4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS | WYETH LLC (US) | 2010-03-18 | — | — | WO | disclosed |