Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP9 | P14780 | 2/20 | 0.30 |
| ▸ | ANPEP | P15144 | 2/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | LAP3 | P28838 | 1/20 | 0.30 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.30 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.30 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942217 | 0.92 | ADAM17 (0.49) | ADAM17P2RX3TGFBR1 | |
| SCHEMBL6945855 | 0.90 | ADAM17 (0.48) | ADAM17P2RX3TGFBR1 | |
| SCHEMBL6947352 | 0.90 | ADAM17 (0.51) | ADAM17P2RX3MMP2MMP9ANPEP | |
| SCHEMBL6940024 | 0.89 | ADAM17 (0.48) | ADAM17CTSDBACE1BACE2TSHR | |
| SCHEMBL6943197 | 0.89 | ADAM17 (0.46) | ADAM17P2RX3 | |
| SCHEMBL6945960 | 0.87 | ADAM17 (0.51) | ADAM17P2RX3MMP2MMP9ANPEP | |
| SCHEMBL6937788 | 0.87 | ADAM17 (0.51) | ADAM17P2RX3MMP2MMP9ANPEP | |
| SCHEMBL6943375 | 0.87 | ADAM17 (0.53) | ADAM17P2RX3MMP2MMP9ANPEP | |
| SCHEMBL6946888 | 0.87 | ADAM17 (0.48) | ADAM17P2RX3CTSKMMP2MMP9 | |
| SCHEMBL6947109 | 0.86 | ADAM17 (0.57) | ADAM17P2RX3CTSKMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |