Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 16/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938432 | 0.78 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL8241153 | 0.78 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL13783984 | 0.77 | HDAC1 (0.67) | HDAC3HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL8190979 | 0.76 | HSD17B10 (0.55) | HSD17B10 | |
| SCHEMBL26393846 | 0.76 | HSD17B10 (0.65) | HSD17B10 | |
| SCHEMBL13983936 | 0.76 | HSD17B10 (0.59) | HSD17B10 | |
| SCHEMBL1937918 | 0.75 | HDAC3 (1.00) | HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL31673854 | 0.75 | HDAC3 (1.00) | HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7095242 | 0.74 | POLB (0.68) | HSD17B10 | |
| SCHEMBL9633498 | 0.74 | FAAH (0.55) | HDAC3HDAC1HDAC2HDAC10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |