Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 12/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234083 | 0.92 | HDAC1 (0.53) | HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL3261607 | 0.85 | HDAC3 (0.54) | HDAC3HDAC1 | |
| SCHEMBL3238636 | 0.80 | HDAC3 (0.36) | HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL3240756 | 0.78 | HDAC3 (0.59) | HDAC3HDAC1 | |
| SCHEMBL3238234 | 0.75 | HDAC1 (0.70) | HDAC3HDAC1HDAC2NCOR2HDAC4 | |
| SCHEMBL27481150 | 0.73 | SMN1; SMN2 (0.54) | — | |
| SCHEMBL15947689 | 0.72 | POLB (0.57) | — | |
| SCHEMBL21533583 | 0.71 | ALDH1A1 (0.59) | — | |
| SCHEMBL3237865 | 0.71 | HDAC3 (0.53) | HDAC3HDAC1HDAC2NCOR2HDAC4 | |
| SCHEMBL3233788 | 0.71 | HDAC1 (0.69) | HDAC3HDAC1HDAC2NCOR2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |