Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | POLA1 | P09884 | 1/20 | 0.45 |
| ▸ | ANTXR2 | P58335 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA3 | P07451 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA6 | P23280 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053528 | 0.89 | CYP1A2 (0.50) | GAAKMT2AMEN1ESR1ESR2 | |
| SCHEMBL9053651 | 0.87 | KMT2A (0.50) | GAAKMT2AMEN1ESR1ESR2 | |
| SCHEMBL9054334 | 0.87 | PTGS2 (0.51) | PTGS2GAAMAPTALDH1A1POLB | |
| SCHEMBL7632373 | 0.86 | GAA (0.53) | GAAKMT2AMEN1ESR1ESR2 | |
| SCHEMBL9052978 | 0.86 | PTGS2 (0.47) | PTGS2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL9054847 | 0.86 | HTT (0.54) | GAAKMT2AMEN1ESR1ESR2 | |
| SCHEMBL9054697 | 0.85 | KMT2A (0.47) | GAAKMT2AMEN1ESR1ESR2 | |
| SCHEMBL9059038 | 0.85 | KMT2A (0.48) | GAAKMT2AMEN1ESR1ESR2 | |
| SCHEMBL9052909 | 0.85 | SNCA (0.49) | GAAKMT2AMEN1ESR1ESR2 | |
| SCHEMBL9054965 | 0.85 | PTGS2 (0.48) | PTGS2GAAKMT2AMEN1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888292-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY ALPHAvBETA3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2001-10-31 | — | — | EP | disclosed |
| EP-0729933-B1 | Tricyclic derivatives, their preparation, their use in the preparation of optically active or racemic colchicine, thiocolchicine and analogues or derivatives, and intermediates | HOECHST MARION ROUSSEL INC (FR) | 2000-01-26 | — | — | EP | disclosed |
| EP-0888292-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY $g(a)v$g(b)3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | HOECHST MARION ROUSSEL (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034865-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY αvβ3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | HOECHST MARION ROUSSEL (FR) | 1997-09-25 | — | — | WO | disclosed |
| EP-0729933-A1 | Tricyclic derivatives, their preparation, their use in the preparation of optically active or racemic colchicine, thiocolchicine and analogues or derivatives, and intermediates | ROUSSEL-UCLAF (FR) | 1996-09-04 | — | — | EP | disclosed |
| WO-1996008483-A1 | GALLIC ACID DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR USE AS DRUGS | ROUSSEL UCLAF (FR) | 1996-03-21 | — | — | WO | disclosed |
| EP-0491600-A1 | Process for the regiospecific monofunctionalisation of a phenolic hydroxy group of a polyphenol | ROUSSEL UCLAF (FR) | 1992-06-24 | — | — | EP | disclosed |