Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 5/20 | 0.36 |
| ▸ | CACNG8 | Q8WXS5 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744548 | 0.84 | MPL (0.41) | MPLALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL8074941 | 0.82 | PDE2A (0.33) | MPLGRIN2BALDH1A1TDP1MAPT | |
| SCHEMBL3790638 | 0.82 | KCNH2 (0.45) | CYP1A2CYP3A4CYP2C19ALDH1A1ADRA2B | |
| SCHEMBL2848722 | 0.79 | MPL (0.41) | MPLCYP3A4ALDH1A1ADRA2BPTGS1 | |
| SCHEMBL8653715 | 0.79 | GRIA1 (0.48) | GRIA1CACNG8CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29893374 | 0.79 | ALDH1A1 (0.50) | MPLCYP1A2CYP3A4CYP2C19GRIN2B | |
| SCHEMBL112134 | 0.79 | ALDH1A1 (0.50) | MPLCYP1A2CYP3A4CYP2C19GRIN2B | |
| SCHEMBL12480337 | 0.78 | MPL (0.51) | MPLCYP3A4ALDH1A1ADRA2BPTGS1 | |
| Hydrochloric Acid SCHEMBL4379610 | 0.77 | ALDH1A1 (0.48) | MPLCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL21603543 | 0.76 | GRIA1 (0.42) | MPLGRIA1CACNG8P2RX7GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235939-B1 | TRIFLUOROALKOXY-5-CHLOROANILINE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-05-22 | — | — | US | claimed |
| EP-0546391-A2 | Process for the preparation of fluorine containing anilines. | BAYER AG (DE) | 1993-06-16 | — | — | EP | claimed |
| US-6235939-B1 | TRIFLUOROALKOXY-5-CHLOROANILINE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-05-22 | — | — | US | disclosed |
| US-6077973-A | Process for the preparation of anilines which contain fluorine and new anilines which contain fluorine | BAYER AKTIENGESELLSCHAFT (DE) | 2000-06-20 | — | — | US | disclosed |
| EP-0546391-B1 | Process for the preparation of fluorine containing anilines. | BAYER AG (DE) | 1996-05-08 | — | — | EP | disclosed |
| EP-0546391-A2 | Process for the preparation of fluorine containing anilines. | BAYER AG (DE) | 1993-06-16 | — | — | EP | disclosed |