Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 5/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694727 | 0.95 | PI4KB (0.48) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL653518 | 0.84 | PI4KB (0.57) | PI4KBP2RY12DGAT1LIMK2KIT | |
| SCHEMBL654042 | 0.84 | PI4KB (0.56) | PI4KBSMN1; SMN2KITALDH1A1TSHR | |
| SCHEMBL655731 | 0.81 | PI4KB (0.59) | PI4KBSMN1; SMN2KITALDH1A1TSHR | |
| SCHEMBL793817 | 0.81 | PI4KB (0.35) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL655119 | 0.79 | PI4KB (0.59) | PI4KBSMN1; SMN2ADORA2BALDH1A1MEN1 | |
| SCHEMBL653942 | 0.78 | PI4KB (0.64) | PI4KBSMN1; SMN2ADORA2BALDH1A1MEN1 | |
| SCHEMBL1720411 | 0.77 | PI4KB (0.57) | PI4KBSMN1; SMN2ADORA2BALDH1A1TSHR | |
| SCHEMBL653069 | 0.76 | PI4KB (0.61) | PI4KBSMN1; SMN2ALDH1A1MEN1POLB | |
| SCHEMBL654187 | 0.76 | PI4KB (0.48) | PI4KBSMN1; SMN2ADORA2BALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |