Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.34 |
| ▸ | TSHR | P16473 | 6/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 6/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3697841 | 0.78 | MKNK2 (0.49) | MKNK2LTA4HFDPSCYP1A2CYP3A4 | |
| SCHEMBL680855 | 0.77 | FGFR1 (0.56) | MKNK2LTA4HCYP1A2CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL4456679 | 0.76 | FGFR1 (0.54) | MKNK2LTA4HCYP1A2CYP3A4TSHR | |
| SCHEMBL3027720 | 0.74 | PI4KA (0.57) | MKNK2LTA4HCYP1A2CYP3A4TSHR | |
| SCHEMBL467133 | 0.74 | MKNK2 (0.47) | MKNK2LTA4HFDPSCYP1A2CYP3A4 | |
| SCHEMBL28580330 | 0.73 | MKNK2 (0.46) | MKNK2LTA4HFDPSCYP1A2CYP3A4 | |
| SCHEMBL28189820 | 0.72 | MKNK2 (0.42) | MKNK2LTA4HFDPSCYP1A2CYP3A4 | |
| SCHEMBL16863762 | 0.71 | MKNK2 (0.47) | MKNK2FDPSCYP1A2CYP3A4TSHR | |
| SCHEMBL1812901 | 0.70 | MKNK2 (0.43) | MKNK2LTA4HFDPSCYP1A2CYP3A4 | |
| SCHEMBL381111 | 0.69 | MKNK2 (0.40) | MKNK2LTA4HFDPSHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616469-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037226-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |