Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | STS | P08842 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553555 | 0.87 | GPR119 (0.54) | SMN1; SMN2THRBGAASTSGPR119 | |
| SCHEMBL1513166 | 0.86 | GPR119 (0.53) | SMN1; SMN2THRBGAASTSGPR119 | |
| SCHEMBL30233524 | 0.86 | GPR119 (0.53) | SMN1; SMN2THRBGAASTSGPR119 | |
| SCHEMBL11920838 | 0.85 | GPR119 (0.52) | SMN1; SMN2THRBGAASTSGPR119 | |
| SCHEMBL4675703 | 0.84 | GPR119 (0.51) | SMN1; SMN2THRBGAASTSGPR119 | |
| SCHEMBL3436365 | 0.83 | GPR119 (0.58) | THRBGPR119KDM4EPKMMAPT | |
| SCHEMBL12712658 | 0.83 | GPR119 (0.50) | SMN1; SMN2THRBGAASTSGPR119 | |
| SCHEMBL12712661 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2THRBGAASTSGPR119 | |
| SCHEMBL15637686 | 0.83 | GPR119 (0.50) | SMN1; SMN2THRBGAASTSGPR119 | |
| SCHEMBL11193650 | 0.83 | GAA (0.56) | SMN1; SMN2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |