Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 4/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 12/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7935781 | 0.76 | PSEN1 (0.37) | MMP8MMP3PSEN1PSEN2APH1B | |
| SCHEMBL2170105 | 0.73 | PSEN1 (0.49) | MMP8MMP3PSEN1PSEN2APH1B | |
| SCHEMBL7938296 | 0.73 | PSEN1 (0.39) | MMP8MMP3PSEN1PSEN2APH1B | |
| SCHEMBL13080721 | 0.71 | PSEN1 (0.46) | MMP8MMP3PSEN1PSEN2APH1B | |
| SCHEMBL3155185 | 0.71 | PSEN1 (0.46) | MMP8MMP3PSEN1PSEN2APH1B | |
| SCHEMBL13080724 | 0.63 | PSEN1 (0.45) | MMP8MMP3PSEN1PSEN2APH1B | |
| SCHEMBL2358183 | 0.63 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3137081 | 0.63 | PSEN1 (0.45) | MMP8MMP3PSEN1PSEN2APH1B | |
| SCHEMBL2219745 | 0.62 | ACHE (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2183303 | 0.62 | PSEN1 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028213-A2 | N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 2010-03-11 | — | — | WO | disclosed |