Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001318 | 0.88 | DYRK1A (0.43) | DYRK1AMAPK1HPGDALOX5APHDAC1 | |
| SCHEMBL1002385 | 0.76 | GRM5 (0.47) | DYRK1AMAPK1HPGDALOX5APENPP3 | |
| SCHEMBL1002632 | 0.74 | ABL1 (0.41) | DYRK1AMAPK1HPGDALOX5AP | |
| SCHEMBL1004185 | 0.71 | MAPK1 (0.44) | DYRK1AMAPK1HPGDALOX5APS1PR1 | |
| SCHEMBL27237310 | 0.70 | HDAC1 (0.55) | HDAC1HDAC8HDAC6 | |
| SCHEMBL1002350 | 0.69 | HDAC1 (0.48) | HPGDHDAC1HDAC8HDAC6 | |
| SCHEMBL1002558 | 0.69 | MAPK1 (0.43) | DYRK1AMAPK1HPGDALOX5APPDE10A | |
| SCHEMBL24370250 | 0.68 | MAPK1 (0.50) | DYRK1AMAPK1HPGDCYP11B1CYP11B2 | |
| SCHEMBL1004945 | 0.67 | ALDH1A1 (0.40) | DYRK1AMAPK1HPGDALOX5APS1PR1 | |
| SCHEMBL5845581 | 0.67 | MAPK1 (0.65) | DYRK1AMAPK1HPGDLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010017079-A1 | OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2010-02-11 | — | — | WO | disclosed |