Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.68 |
| ▸ | PDE5A | O76074 | 2/20 | 0.68 |
| ▸ | CDK1 | P06493 | 3/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | UBE2N | P61088 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20164596 | 0.89 | APP (0.56) | APPPDE5ACDK1ESR1KDM4E | |
| SCHEMBL20164511 | 0.85 | CDK1 (0.53) | APPPDE5ACDK1ESR1PDE10A | |
| SCHEMBL7973136 | 0.85 | CCNE2 (0.58) | APPPDE5ACDK1KDM4EALDH1A1 | |
| SCHEMBL8851040 | 0.85 | CDK1 (0.55) | APPPDE5ACDK1ESR1LMNA | |
| SCHEMBL27248399 | 0.82 | PDE4A (0.62) | APPPDE5ACDK1ESR1KMT2A | |
| SCHEMBL7011138 | 0.82 | APP (0.56) | APPPDE5ACDK1ESR1RAD52 | |
| SCHEMBL3444342 | 0.81 | APP (0.55) | APPPDE5ACDK1ESR1RAD52 | |
| SCHEMBL21567259 | 0.81 | APP (0.67) | APPPDE5ACDK1ESR1RAD52 | |
| SCHEMBL1216376 | 0.81 | CDK1 (0.55) | APPPDE5ACDK1ESR1LMNA | |
| SCHEMBL9350959 | 0.81 | RAD52 (0.66) | APPCDK1RAD52KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014045310-A1 | PYRIMIDO[5,4-D]PYRIMIDINE OR PYRIMIDINE DERIVATIVES COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | ZOLLO MASSIMO (IT) | 2014-03-27 | — | — | WO | claimed |
| WO-2014045310-A1 | PYRIMIDO[5,4-D]PYRIMIDINE OR PYRIMIDINE DERIVATIVES COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | ZOLLO MASSIMO (IT) | 2014-03-27 | — | — | WO | disclosed |
| US-6297250-B1 | USEFUL FOR INHIBITING TRANSPORT OF NUCLEOSIDES OR PURINES ACROSS CELL MEMBRANES, THEREBY TO POTENTIATE THE ACTIVITY OF VARIOUS CYTOTOXIC ANTITUMOR DRUGS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-02 | — | — | US | disclosed |
| US-6232312-B1 | ADMINISTERING A COMBINATION OF INDENE AND PYRIMIDO(5,4-D)PYRIMIDINE DERIVATIVES TO TREAT PREPANCREATIC CANCER | CELL PATHWAYS, INC. | 2001-05-15 | — | — | US | disclosed |