Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 2/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7939004 | 0.85 | APP (0.68) | APPPDE5ACDK1KDM4EALDH1A1 | |
| SCHEMBL15619030 | 0.82 | CCNE2 (0.68) | CCNE2CCNE1CDK2APPPDE5A | |
| SCHEMBL5828183 | 0.81 | CCNE2 (0.52) | CCNE2CCNE1CDK2PDE2AAPP | |
| SCHEMBL11866701 | 0.79 | CA12 (0.62) | PDE2AAPPKDM4E | |
| SCHEMBL3106597 | 0.77 | APP (0.85) | PDE2AAPPPDE5AEGFRKDM4E | |
| SCHEMBL20164511 | 0.76 | CDK1 (0.53) | CCNE2CCNE1CDK2APPPDE5A | |
| SCHEMBL20164596 | 0.76 | APP (0.56) | CCNE2CCNE1CDK2APPPDE5A | |
| SCHEMBL6152647 | 0.75 | CDK1 (0.82) | CCNE2CCNE1CDK2CDK1KDM4E | |
| SCHEMBL22866338 | 0.75 | PDE2A (0.52) | CCNE2CCNE1CDK2PDE2AHSD17B10 | |
| SCHEMBL6152650 | 0.74 | CTSL (0.69) | CCNE2CCNE1CDK2PDE2ACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297250-B1 | USEFUL FOR INHIBITING TRANSPORT OF NUCLEOSIDES OR PURINES ACROSS CELL MEMBRANES, THEREBY TO POTENTIATE THE ACTIVITY OF VARIOUS CYTOTOXIC ANTITUMOR DRUGS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-02 | — | — | US | disclosed |