Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.35 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | RXRG | P48443 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3209523 | 0.87 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4DLTC4S | |
| SCHEMBL3208478 | 0.85 | PDE4D (0.39) | PDE4APDE4BPDE4CPDE4DLTC4S | |
| SCHEMBL3201072 | 0.84 | PDE4B (0.53) | PDE4APDE4BPDE4CPDE4DLTC4S | |
| SCHEMBL3193794 | 0.83 | MRGPRX4 (0.42) | RXRALTC4SIMPDH2PPARG | |
| SCHEMBL3215109 | 0.82 | PDE4D (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3208802 | 0.81 | TSHR (0.49) | LTC4SIMPDH2AAK1 | |
| SCHEMBL3117544 | 0.79 | HRH4 (0.39) | RXRAPDE4DRXRBRXRGPPARG | |
| SCHEMBL3194788 | 0.79 | TSHR (0.44) | PDE4APDE4BPDE4CPDE4DLTC4S | |
| SCHEMBL3203543 | 0.79 | PDE4D (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3129488 | 0.78 | RXRA (0.39) | RXRAPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |