Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6559419 | 0.90 | MAPT (0.35) | PDE10AMAPTALDH1A1MEN1RAB9A | |
| Hydrochloric Acid SCHEMBL9126330 | 0.79 | MAPT (0.40) | MAPTALDH1A1MEN1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL7939285 | 0.79 | CYP1A2 (0.32) | PDE10AALDH1A1MEN1KMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL8917407 | 0.78 | EDNRB (0.39) | PDE10A | |
| Hydrochloric Acid SCHEMBL8606301 | 0.78 | DNMT1 (0.41) | MAPTALDH1A1MEN1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL7931307 | 0.78 | MAPT (0.35) | PDE10AMAPTALDH1A1MEN1RAB9A | |
| Hydrochloric Acid SCHEMBL5352654 | 0.76 | HTR2A (0.47) | PDE10AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8915890 | 0.74 | EDNRB (0.38) | PDE10A | |
| Hydrochloric Acid SCHEMBL8917342 | 0.73 | HTR2A (0.36) | PDE10A | |
| Hydrochloric Acid SCHEMBL7931279 | 0.73 | DNMT1 (0.36) | MAPTALDH1A1MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123938-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0672675-A1 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-09-20 | — | — | EP | disclosed |
| US-5451649-A | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-09-19 | — | — | US | disclosed |