SCHEMBL7939610

SCHEMBL7939610

NC1=NC2(CCN(C(=O)OCCc3ccccc3)CC2)Nc2cccc(F)c21

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 9/20 0.76
NOS1 P29475 7/20 0.76
NOS3 P29474 2/20 0.76
GRIN2B Q13224 1/20 0.39
KCNH2 Q12809 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
GRM5 P41594 1/20 0.38
HTR2A P28223 3/20 0.38
OPRM1 P35372 3/20 0.38
HTR1A P08908 2/20 0.38
DRD4 P21917 2/20 0.38
HRH1 P35367 2/20 0.38
ADORA3 P0DMS8 2/20 0.37
HTR7 P34969 2/20 0.37
SIGMAR1 Q99720 1/20 0.37
OPRD1 P41143 3/20 0.36
OPRK1 P41145 2/20 0.36
CACNA1F O60840 1/20 0.36
DRD2 P14416 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8381696 0.99 NOS2 (0.75) NOS2NOS1NOS3GRIN2BKCNH2
SCHEMBL7938445 0.95 NOS2 (0.73) NOS2NOS1NOS3GRIN2BKCNH2
SCHEMBL7943052 0.94 NOS2 (0.72) NOS2NOS1NOS3GRIN2BKCNH2
Hydrochloric Acid SCHEMBL8379953 0.94 NOS2 (0.72) NOS2NOS1NOS3GRIN2BKCNH2
Hydrochloric Acid SCHEMBL8376657 0.93 NOS2 (0.71) NOS2NOS1NOS3GRIN2BKCNH2
Hydrochloric Acid SCHEMBL8381880 0.91 NOS2 (0.71) NOS2NOS1NOS3KCNH2OPRD1
SCHEMBL7940561 0.90 NOS2 (0.70) NOS2NOS1NOS3GRIN2BKCNH2
SCHEMBL7931930 0.90 NOS2 (0.75) NOS2NOS1NOS3KCNH2OPRD1
Hydrochloric Acid SCHEMBL8376646 0.90 NOS2 (0.69) NOS2NOS1NOS3GRIN2BKCNH2
Hydrochloric Acid SCHEMBL8377001 0.89 NOS2 (0.73) NOS2NOS1NOS3KCNH2OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248745-B1 MIXTURE COMPRISING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR AND A 1,2-DIHYDRO-4-AMINOQUINAZOLINE DERIVATIVE INHIBITOR OF INDUCED NITRIC OXIDE SYNTHASE (INOS); NON-STEROIDAL ANTIINFLAMMATORY AGENTS ASTRAZENECA AB (SE) 2001-06-19 US claimed