Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.53 |
| ▸ | GRM5 | P41594 | 9/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2811392 | 0.88 | PDK4 (0.60) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL2239831 | 0.87 | NAMPT (0.66) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL31009246 | 0.85 | PDK4 (0.52) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL1366854 | 0.85 | PDK4 (0.52) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL15709719 | 0.85 | PDK4 (0.53) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL19989639 | 0.85 | NAMPT (0.67) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL7831576 | 0.84 | PDK4 (0.58) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL3169756 | 0.83 | PDK4 (0.55) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL1364792 | 0.83 | PDK4 (0.57) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL29914645 | 0.83 | PDK4 (0.57) | PDK4NAMPTGRM1GRM5HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |