Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10455271 | 0.78 | TDP1 (0.45) | CYP3A4TDP1ESR1ESR2ALDH1A1 | |
| SCHEMBL1518031 | 0.78 | TDP1 (0.45) | CYP3A4TDP1ESR1ESR2KDM4E | |
| SCHEMBL4973930 | 0.78 | TDP1 (0.45) | CYP3A4TDP1ESR1ESR2NOS3 | |
| SCHEMBL7113981 | 0.78 | TDP1 (0.45) | CYP3A4TDP1ESR1ESR2NOS3 | |
| SCHEMBL24649619 | 0.77 | CYP3A4 (0.39) | CYP3A4TDP1ESR1ESR2HPGD | |
| Ammonia Solution, Strong SCHEMBL4202998 | 0.76 | TDP1 (0.43) | CYP3A4TDP1ESR1ESR2KDM4E | |
| SCHEMBL5034105 | 0.74 | CES2 (0.42) | CYP3A4TDP1ESR1ESR2ALDH1A1 | |
| SCHEMBL15363980 | 0.73 | CYP3A4 (0.36) | CYP3A4TDP1ESR1ESR2ALDH1A1 | |
| SCHEMBL21788617 | 0.72 | CYP3A4 (0.39) | CYP3A4TDP1ESR1ESR2ALDH1A1 | |
| SCHEMBL12730121 | 0.72 | CYP3A4 (0.35) | CYP3A4TDP1ESR1ESR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9868805-B2 | Polydienes and diene copolymers having organophosphine functionality | BRIDGESTONE CORPORATION (JP) | 2018-01-16 | — | — | US | disclosed |
| EP-2844678-B1 | POLYDIENES AND DIENE COPOLYMERS HAVING ORGANOPHOSPHINE FUNCTIONALITY | BRIDGESTONE CORP (JP) | 2017-02-22 | — | — | EP | disclosed |
| US-9499651-B2 | Copolymers of conjugated dienes and vinyl organophosphines prepared by anionic polymerization | BRIDGESTONE CORPORATION (JP) | 2016-11-22 | — | — | US | disclosed |
| US-9127109-B2 | Preparation of functional polymers phosphorus-containing organometal initiators | BRIDGESTONE CORPORATION (JP) | 2015-09-08 | — | — | US | disclosed |
| US-20150126675-A1 | Polydienes And Diene Copolymers Having Organophosphine Functionality | BRIDGESTONE CORPORATION (JO) | 2015-05-07 | — | — | US | disclosed |
| EP-2844678-A1 | POLYDIENES AND DIENE COPOLYMERS HAVING ORGANOPHOSPHINE FUNCTIONALITY | Bridgestone Corporation (JP) | 2015-03-11 | — | — | EP | disclosed |
| US-20140275428-A1 | Copolymers Of Conjugated Dienes And Vinyl Organophosphines Prepared By Anionic Polymerization | BRIDGESTONE CORPORATION (JP) | 2014-09-18 | — | — | US | disclosed |
| US-20130296480-A1 | PREPARATION OF FUNCTIONAL POLYMERS PHOSPHORUS-CONTAINING ORGANOMETAL INITIATORS | BRIDGESTONE CORPORATION (JP) | 2013-11-07 | — | — | US | disclosed |
| WO-2013166124-A1 | POLYDIENES AND DIENE COPOLYMERS HAVING ORGANOPHOSPHINE FUNCTIONALITY | BRIDGESTONE CORPORATION (JP) | 2013-11-07 | — | — | WO | disclosed |
| US-6187890-B1 | CROSSLINK BY REACTION OF ALIPHATICALLY UNSATURATED GROUPS WITH SI-BONDED HYDROGEN (HYDROSILYLATION) IN THE PRESENCE OF A CATALYST, TYPICALLY A PLATINUM COMPOUND | WACKER-CHEMIE GMBH (DE) | 2001-02-13 | — | — | US | disclosed |
| EP-0982370-B1 | Curable polysiloxane compositions | WACKER CHEMIE GMBH (DE) | 2000-12-20 | — | — | EP | disclosed |
| EP-0982370-A1 | Curable polysiloxane compositions | Wacker-Chemie GmbH (DE) | 2000-03-01 | — | — | EP | disclosed |