Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12302316 | 0.90 | RAB9A (0.42) | BACE1RAB9ANPC1SMN1; SMN2CHRNA7 | |
| SCHEMBL7941730 | 0.84 | BACE1 (0.59) | BACE1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL7935757 | 0.84 | RAB9A (0.50) | BACE1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL7944905 | 0.83 | BACE1 (0.43) | BACE1RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL7943474 | 0.83 | BACE1 (0.43) | BACE1AURKAAURKB | |
| SCHEMBL7940504 | 0.81 | PTGDR2 (0.40) | BACE1F10CHRNA7AURKAAURKB | |
| SCHEMBL7943475 | 0.81 | BACE1 (0.47) | BACE1RAB9ANPC1SMN1; SMN2AURKA | |
| SCHEMBL7946719 | 0.81 | BACE1 (0.43) | BACE1AURKAAURKBCASP3SENP8 | |
| SCHEMBL7941823 | 0.81 | BACE1 (0.46) | BACE1ALDH1A1AURKAAURKB | |
| SCHEMBL7944814 | 0.80 | BACE1 (0.52) | BACE1RAB9ANPC1SMN1; SMN2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |