Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 11/20 | 0.55 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8378263 | 0.99 | NOS2 (0.54) | NOS2NOS1TAAR1HTR2AIDO1 | |
| SCHEMBL7806690 | 0.84 | NOS2 (0.56) | NOS2NOS1HTR2ANOS3 | |
| Hydrochloric Acid SCHEMBL8518054 | 0.83 | NOS2 (0.55) | NOS2NOS1HTR2ANOS3 | |
| SCHEMBL27490818 | 0.82 | NOS2 (0.48) | NOS2 | |
| SCHEMBL7802794 | 0.72 | NOS2 (1.00) | NOS2NOS1NOS3 | |
| SCHEMBL7943448 | 0.70 | NOS2 (0.54) | NOS2 | |
| Hydrochloric Acid SCHEMBL8378309 | 0.70 | NOS2 (0.96) | NOS2NOS1NOS3 | |
| SCHEMBL13356721 | 0.70 | NOS2 (0.56) | NOS2NOS1NOS3 | |
| Hydrochloric Acid SCHEMBL8379616 | 0.69 | NOS2 (0.52) | NOS2 | |
| SCHEMBL7802803 | 0.69 | NOS2 (0.68) | NOS2HTR2AIDO1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248745-B1 | MIXTURE COMPRISING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR AND A 1,2-DIHYDRO-4-AMINOQUINAZOLINE DERIVATIVE INHIBITOR OF INDUCED NITRIC OXIDE SYNTHASE (INOS); NON-STEROIDAL ANTIINFLAMMATORY AGENTS | ASTRAZENECA AB (SE) | 2001-06-19 | — | — | US | claimed |