Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 12/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12248368 | 0.77 | NOTUM (0.45) | NOTUMEGLN2CYP19A1KCNJ1 | |
| SCHEMBL5612789 | 0.76 | NOTUM (0.56) | NOTUMEGLN2CYP19A1CHRM1KCNJ1 | |
| SCHEMBL30046228 | 0.76 | NOTUM (0.56) | NOTUMEGLN2CYP19A1CHRM1KCNJ1 | |
| SCHEMBL17725711 | 0.73 | KCNJ1 (0.58) | NOTUMKCNJ1 | |
| SCHEMBL10136885 | 0.73 | KDM4E (0.50) | NOTUM | |
| SCHEMBL1459170 | 0.72 | NOTUM (0.38) | NOTUMEGLN2CYP19A1 | |
| SCHEMBL20409464 | 0.72 | NOTUM (0.61) | NOTUMCYP19A1 | |
| SCHEMBL28173190 | 0.71 | KCNJ1 (0.37) | NOTUMEGLN2MAP3K5KCNJ1 | |
| SCHEMBL232012 | 0.71 | MAPT (0.55) | CHRM1 | |
| SCHEMBL30948251 | 0.69 | NOTUM (0.48) | NOTUMEGLN2CYP19A1MAP3K5KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |