Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.31 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16039381 | 0.75 | HCRTR2 (0.43) | NOTUMEGLN2HCRTR1HCRTR2MYC | |
| SCHEMBL17768591 | 0.72 | NOTUM (0.35) | NOTUMHCRTR1HCRTR2MYCHCAR2 | |
| SCHEMBL29483818 | 0.71 | ALDH1A1 (0.44) | HCAR2ALDH1A1 | |
| SCHEMBL7940956 | 0.71 | NOTUM (0.44) | KCNJ1NOTUMEGLN2MAP3K5 | |
| SCHEMBL20774263 | 0.69 | NOTUM (0.37) | NOTUMHCRTR1HCRTR2HCAR2 | |
| SCHEMBL18588653 | 0.69 | HCRTR1 (0.56) | NOTUMEGLN2HCRTR1HCRTR2MYC | |
| SCHEMBL30112052 | 0.68 | HPGD (0.39) | MYCHCAR2KDM4EALDH1A1MAPT | |
| SCHEMBL7422568 | 0.68 | HPGD (0.39) | MYCHCAR2KDM4EALDH1A1MAPT | |
| SCHEMBL18993134 | 0.68 | LMNA (0.63) | KCNJ1EGLN2TET2OGFOD1TET1 | |
| SCHEMBL19481007 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107106558-A | Having a2AAminopyrazine compounds with antagonist properties | 默沙东公司 | 2017-08-29 | — | — | CN | disclosed |