Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7944168 | 0.83 | ATM (0.34) | MEN1KMT2AATMSIGMAR1HTR6 | |
| Hydrochloric Acid SCHEMBL818470 | 0.83 | HTR2A (0.33) | MEN1KMT2ASIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL6280682 | 0.71 | HDAC3 (0.37) | MEN1KMT2AATM | |
| Hydrochloric Acid SCHEMBL215793 | 0.70 | HTR2A (0.36) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL7951350 | 0.70 | HTR2A (0.36) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL1538529 | 0.69 | HTR2A (0.37) | MEN1KMT2ASIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL964733 | 0.69 | HTR2A (0.37) | MEN1KMT2ASIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL4479585 | 0.69 | RET (0.38) | MEN1KMT2ASIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL216949 | 0.69 | HTR2A (0.33) | MEN1KMT2ASIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL15283336 | 0.69 | HTR2A (0.37) | MEN1KMT2ASIGMAR1HTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313240-B1 | ETHYLENE IS COPOLYMERIZED WITH AN .ALPHA.-OLEFIN HAVING THREE OR MORE CARBONS BY USE OF AN OLEFIN POLYMERIZATION CATALYST COMPRISING HAFNIUM METALLOCENE COMPOUND, IONIZING COMPOUND, OGRANOALUMINUM COMPOUND | TOSOH CORPORATION (JP) | 2001-11-06 | — | — | US | disclosed |
| US-5817590-A | METALLOCENE, IONIZING IONIC COMPOUND, ORGANOALUMINUM COMPOUND, LEWIS BASE | TOSOH CORPORATION (JP) | 1998-10-06 | — | — | US | disclosed |
| EP-0612768-B1 | Process for producing ethylene/alpha-olefin copolymer | TOSOH CORP (JP) | 1997-11-12 | — | — | EP | disclosed |
| EP-0648786-B1 | Process for producing alpha-olefin polymer | TOSOH CORP (JP) | 1997-07-16 | — | — | EP | disclosed |
| US-5576259-A | POLYMERIZATION CATALYST INCLUDING METALLOCENE COMPOUND, IONIC COMPOUND, ORGANOALUMINUM COMPOUND, AND LEWIS BASE | TOSOH CORPORATION (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0708117-A1 | Process for producing copolymer rubber | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0648786-A1 | Process for producing alpha-olefin polymer | Tosoh Corporation (JP) | 1995-04-19 | — | — | EP | disclosed |
| EP-0612768-A1 | Process for producing ethylene/alpha-olefin copolymer | TOSOH CORPORATION (JP) | 1994-08-31 | — | — | EP | disclosed |