Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL15941029 | 0.98 | CA14 (0.36) | CA14DPP4ALDH1A1L3MBTL1HDAC6 | |
| SCHEMBL25282321 | 0.90 | CA14 (0.41) | CA14DPP4ALDH1A1L3MBTL1HDAC6 | |
| SCHEMBL3020149 | 0.86 | CA14 (0.49) | CA14DPP4ALDH1A1L3MBTL1HDAC6 | |
| SCHEMBL956549 | 0.86 | ALDH1A1 (0.42) | CA14DPP4ALDH1A1L3MBTL1HDAC6 | |
| SCHEMBL3024404 | 0.85 | CA14 (0.48) | CA14DPP4ALDH1A1L3MBTL1HDAC6 | |
| SCHEMBL15942130 | 0.85 | CA14 (0.38) | CA14DPP4ALDH1A1L3MBTL1HDAC6 | |
| SCHEMBL15694959 | 0.85 | CA14 (0.38) | CA14DPP4ALDH1A1L3MBTL1HDAC6 | |
| SCHEMBL15668049 | 0.85 | SSTR4 (0.41) | CA14DPP4ALDH1A1L3MBTL1HDAC6 | |
| SCHEMBL12924143 | 0.84 | CA14 (0.47) | CA14L3MBTL1HDAC6HDAC1HDAC2 | |
| SCHEMBL505669 | 0.82 | CA14 (0.46) | CA14L3MBTL1HDAC6HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3521288-B1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | HOFFMANN LA ROCHE (CH) | 2021-09-08 | — | — | EP | disclosed |
| WO-2010011912-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |