Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Atropine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 1.00 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 1.00 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 4/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hyoscyamine SCHEMBL41316 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 | |
| Atropine SCHEMBL41317 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 | |
| Atropine SCHEMBL17775090 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 | |
| Atropine SCHEMBL2728129 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 | |
| Atropine SCHEMBL14946873 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 | |
| Atropine SCHEMBL8854381 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 | |
| Atropine SCHEMBL25020 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 | |
| Atropine SCHEMBL2812 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 | |
| Atropine SCHEMBL249586 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 | |
| Hyoscyamine SCHEMBL4957671 | 1.00 | CHRM1 (1.00) | CHRM1CHRM2CHRM5CHRM3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016692-A1 | PROCESS FOR PREPARATION OF ATROPINE | ROUVER INVESTMENT S.À.R.L (LU) | 2016-02-04 | — | — | WO | disclosed |
| WO-2014186790-A1 | CARDIAC ARREST EVENT (CODE) SUPPORT SYSTEM, EQUIPMENT AND METHDOLOGIES PROVIDING RECORDATION, DOCUMENTATION, ANALYSIS, FEEDBACK AND POST EVENT PROCESSING | SCIENTIFIC PATHWAYS INTERNATIONAL, LLC (US) | 2014-11-20 | — | — | WO | disclosed |
| CN-1187618-C | Reagent box for fast detecting methyl amphetamine and its preparation process | KAICHUANG BIOTECHNOLOGY CO LTD (CN) | 2005-02-02 | — | — | CN | disclosed |
| CN-1410770-A | Reagent box for fast detecting methyl amphetamine and its preparation process | KAICHUANG BIOTECHNOLOGY CO LTD (CN) | 2003-04-16 | — | — | CN | disclosed |
| EP-1117409-A2 | USE OF BENZENESULFONYL(THIO)UREAS FOR THE TREATMENT OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM | Aventis Pharma Deutschland GmbH (DE) | 2001-07-25 | — | — | EP | disclosed |
| US-6162186-A | Non-invasive method for diagnosing alzheimer's disease in a patient | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2000-12-19 | — | — | US | disclosed |
| EP-1011415-A1 | NON-INVASIVE METHOD FOR DIAGNOSING ALZHEIMER'S DISEASE IN A PATIENT | BETH ISRAEL HOSPITAL (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-2000015204-A2 | USE OF BENZENESULFONYL(THIO)UREAS FOR THE TREATMENT AND PROPHYLAXIS OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM AND USE OF BENZENESULFONYL(THIO)UREAS IN COMBINATION WITH BETA-RECEPTOR BLOCKERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-03-23 | — | — | WO | disclosed |
| US-6024707-A | Non-invasive method for diagnosing Alzheimer's disease in a patient | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2000-02-15 | — | — | US | disclosed |
| US-5704369-A | Non-invasive method for diagnosing Alzeheimer's disease in a patient | BETH ISRAEL HOSPITAL ASSOCIATION, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| EP-1011415-A4 | NON-INVASIVE METHOD FOR DIAGNOSING ALZHEIMER'S DISEASE IN A PATIENT | BETH ISRAEL HOSPITAL (US) | 1997-08-18 | — | — | EP | disclosed |
| US-5617872-A | INTRODUCING PHOTOSTIMULATING LIGHT OF PREDETERMINED WAVELENGTH TO PUPIL OF EYE, DETERMINING VELOCITY OF CONSTRICTION, ADMINISTERING NEURAL TRANSMITTER MEDIATOR, NOTING CHANGE IN PUPIL RESPONSE | BETH ISRAEL HOSPITCAL ASSOC. INC. (US) | 1997-04-08 | — | — | US | disclosed |
| WO-1996003070-A1 | NON-INVASIVE METHOD FOR DIAGNOSING ALZHEIMER'S DISEASE IN A PATIENT | BETH ISRAEL HOSPITAL ASSOCIATION (US) | 1996-02-08 | — | — | WO | disclosed |