⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362053 | 1.00 | — | — | |
| SCHEMBL11372978 | 1.00 | — | — | |
| SCHEMBL20530080 | 0.77 | — | — | |
| SCHEMBL794985 | 0.75 | — | — | |
| SCHEMBL6859963 | 0.75 | — | — | |
| SCHEMBL2542167 | 0.75 | — | — | |
| SCHEMBL11632142 | 0.71 | — | — | |
| SCHEMBL11325066 | 0.71 | — | — | |
| SCHEMBL3929 | 0.69 | — | — | |
| SCHEMBL3668694 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3618835-A1 | APRAMYCIN DERIVATIVES | Wayne State University (US) | 2020-03-11 | — | — | EP | claimed |
| WO-2018204358-A1 | APRAMYCIN DERIVATIVES | WAYNE STATE UNIVERSITY (US) | 2018-11-08 | — | — | WO | claimed |
| US-20140309192-A1 | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC, | 2014-10-16 | — | — | US | claimed |
| EP-2776407-A1 | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2014-09-17 | — | — | EP | claimed |
| WO-2013070657-A1 | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2013-05-16 | — | — | WO | claimed |
| EP-0259014-A2 | 5-Deoxy-5-fluorokanamycin B derivatives and processes for the production thereof | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1988-03-09 | — | — | EP | claimed |
| US-4547492-A | 1-N-(ω-Amino-α-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1985-10-15 | — | — | US | claimed |
| EP-0139553-A2 | 1N-(omega-amino-alpha-hydroxyalkanoyl)-2',3'-dideoxykanamycin A and the production of the same | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1985-05-02 | — | — | EP | claimed |
| EP-0048614-B1 | 1-N-ACYLATED AND 1-N-ALKYLATED DERIVATIVES OF 4-0-SUBSTITUTED -2-DEOXYSTREPTAMINE AMINOGLYCOSIDES | ELI LILLY AND COMPANY (US) | 1985-03-20 | — | — | EP | claimed |
| EP-0048613-B1 | 4-0-SUBSTITUTED -2-DEOXYSTREPTAMINE AMINOGLYCOSIDE DERIVATIVES, THEIR PREPARATION AND FORMULATIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1985-01-23 | — | — | EP | claimed |
| US-4468512-A | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides | ELI LILLY AND COMPANY (US) | 1984-08-28 | — | — | US | claimed |
| US-4468513-A | 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides | ELI LILLY AND COMPANY (US) | 1984-08-28 | — | — | US | claimed |
| US-4396609-A | GENTAMICINS | STERLING DRUG INC. (US) | 1983-08-02 | — | — | US | claimed |
| US-4360665-A | 4\"-N-(Substituted)-apramycin antibiotic derivatives and intermediates therefor | ELI LILLY AND COMPANY (US) | 1982-11-23 | — | — | US | claimed |
| EP-0048614-A1 | 1-N-acylated and 1-N-alkylated derivatives of 4-0-substituted -2-deoxystreptamine aminoglycosides | ELI LILLY AND COMPANY (US) | 1982-03-31 | — | — | EP | claimed |
| EP-0048613-A1 | 4-0-Substituted -2-deoxystreptamine aminoglycoside derivatives, their preparation and formulations containing them | ELI LILLY AND COMPANY (US) | 1982-03-31 | — | — | EP | claimed |
| US-4171356-A | 2-Unsubstituted derivatives of 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitois, methods for their use as antibacterial agents and compositions useful therefor | SCHERING CORPORATION (US) | 1979-10-16 | — | — | US | claimed |
| EP-0000473-A1 | Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives | Technobiotic Ltd. (CH) | 1979-02-07 | — | — | EP | claimed |
| US-4136254-A | PROCESS OF SELECTIVELY BLOCKING AMINO FUNCTIONS IN AMINOGLYCOSIDES USING TRANSITION METAL SALTS AND INTERMEDIATES USED THEREBY | SCHERING CORPORATION (US) | 1979-01-23 | — | — | US | claimed |
| US-4053591-A | 5-DEOXY-4,6-DI-O-(AMINOGLYCOSYL)-1,3-DIAMINOCYCLITOLS, METHODS FOR THEIR MANUFACTURE, METHOD FOR THEIR USE AS ANTIBACTERIAL AGENTS AND COMPOSITIONS USEFUL THEREFOR | SCHERING CORPORATION (US) | 1977-10-11 | — | — | US | claimed |