SCHEMBL7943558

SCHEMBL7943558

CC(C)Oc1ccc2c(c1)/C(=C/CN)CCCC2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 3/20 0.39
MTNR1A P48039 3/20 0.39
MTNR1B P49286 3/20 0.39
ABCB1 P08183 1/20 0.39
EZH2 Q15910 1/20 0.36
CES2 O00748 1/20 0.35
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
POLB P06746 1/20 0.34
ADCY8 P40145 1/20 0.34
ADCY1 Q08828 1/20 0.34
CYP19A1 P11511 2/20 0.33
CYP11B2 P19099 2/20 0.33
LMNA P02545 2/20 0.33
TP53 P04637 1/20 0.33
THRB P10828 1/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 2/20 0.33
TSHR P16473 2/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7943559 1.00 NQO2 (0.39) NQO2MTNR1AMTNR1BABCB1EZH2
SCHEMBL7953871 0.85 ABCB1 (0.52) NQO2MTNR1AMTNR1BABCB1MAOA
SCHEMBL7953870 0.85 ABCB1 (0.52) NQO2MTNR1AMTNR1BABCB1MAOA
SCHEMBL1289479 0.82 ABCB1 (0.55) NQO2MTNR1AMTNR1BABCB1MAOB
SCHEMBL1289480 0.82 ABCB1 (0.55) NQO2MTNR1AMTNR1BABCB1MAOB
SCHEMBL1289475 0.82 ABCB1 (0.55) NQO2MTNR1AMTNR1BABCB1MAOB
Hydrochloric Acid SCHEMBL1289493 0.81 ABCB1 (0.54) NQO2MTNR1AMTNR1BABCB1MAOB
Hydrochloric Acid SCHEMBL1289505 0.81 ABCB1 (0.54) NQO2MTNR1AMTNR1BABCB1MAOB
Hydrochloric Acid SCHEMBL1289494 0.81 ABCB1 (0.54) NQO2MTNR1AMTNR1BABCB1MAOB
SCHEMBL7951379 0.80 MTNR1A (0.53) NQO2MTNR1AMTNR1BABCB1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235789-B1 GLANDULAR DISORDERS; SLEEP DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
EP-0781271-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-02 EP disclosed
WO-1996008466-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-03-21 WO disclosed