Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 0.58 |
| ▸ | NOS1 | P29475 | 7/20 | 0.58 |
| ▸ | NOS3 | P29474 | 5/20 | 0.58 |
| ▸ | OTC | P00480 | 1/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.40 |
| ▸ | BHMT | Q93088 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL1886681 | 1.00 | NOS2 (0.58) | NOS2NOS1NOS3OTCDDAH1 | |
| Arginine SCHEMBL27682442 | 0.95 | NOS2 (0.53) | NOS2NOS1NOS3OTCDDAH1 | |
| Arginine SCHEMBL15322571 | 0.94 | NOS2 (0.52) | NOS2NOS1NOS3OTCDDAH1 | |
| Arginine SCHEMBL15322576 | 0.94 | NOS2 (0.52) | NOS2NOS1NOS3OTCDDAH1 | |
| Arginine SCHEMBL15323739 | 0.90 | NOS2 (0.48) | NOS2NOS1NOS3OTCDDAH1 | |
| Arginine SCHEMBL15323465 | 0.88 | NOS2 (0.46) | NOS2NOS1NOS3OTCDDAH1 | |
| L-Citrulline SCHEMBL28001671 | 0.87 | NOS2 (0.53) | NOS2NOS1NOS3OTCDDAH1 | |
| Arginine SCHEMBL27850376 | 0.87 | NOS2 (0.57) | NOS2NOS1NOS3OTCDDAH1 | |
| Arginine SCHEMBL27850377 | 0.87 | NOS2 (0.57) | NOS2NOS1NOS3OTCDDAH1 | |
| SCHEMBL18121929 | 0.86 | NOS2 (0.61) | NOS2NOS1NOS3OTCDDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001035953-A2 | EXERCISE AND MUSCLE ENHANCEMENT FORMULATIONS | KUHRTS ERIC H (US) | 2001-05-25 | — | — | WO | disclosed |